In 2013, DiMarco had a leading role in the independent film In the Can, which was told in American Sign Language with English subtitles. In 2014 and 2015, he played the recurring role of Garrett Banducci in Switched at Birth on the Freeform network (then ABC).
DiMarco was doing freelance modeling for about a year before he was contacted by America's Next Top Model producers in 2015. They scouted the then 25-year-old via his Instagram account without realizing he was deaf. He was named the winner of the season after beating out Mamé Adjei in the season finale. He is the only deaf contestant in the show's history, and the second male to ever win.
Shortly after winning the competition, DiMarco signed with Wilhelmina Models in New York City.
On March 8, 2016, DiMarco was announced as one of the celebrities who will compete on season 22 of Dancing with the stars" and he ended up winning.
DiMarco doesn't consider himself to be "disabled" by his deafness and sees his high profile as an opportunity to create awareness to the hearing world. He views deafness as an advantage in modeling because he is accustomed to conveying messages without speaking. He also feels that deaf roles should be played by deaf actors.
During an episode of ANTM, DiMarco stated that he has a fraternal twin brother named Nico, who has red hair and that they do not look alike. In Oct, midway through the season of ANTM, DiMarco was asked about his sexuality. He responded that he views himself as sexually "fluid".